Cadmium Toxicity - Toxicology

What is Cadmium?

Cadmium is a naturally occurring heavy metal found in the earth's crust. It is commonly associated with industrial processes such as mining, smelting, and manufacturing of batteries, pigments, and plastic stabilizers. Due to its widespread use, cadmium can accumulate in the environment and enter the human body through various routes.

How Does Cadmium Enter the Human Body?

Cadmium exposure primarily occurs through inhalation of contaminated air, ingestion of contaminated food and water, and less frequently, through dermal contact. Foods such as rice, leafy vegetables, and shellfish can have high cadmium concentrations. Cigarette smoke is another significant source of cadmium exposure.

What Are the Health Effects of Cadmium Exposure?

Acute cadmium toxicity can manifest as severe gastrointestinal symptoms if ingested, or as respiratory distress if inhaled. Chronic exposure, however, is more insidious and can lead to serious health problems including:
Kidney Damage: Cadmium accumulates in the kidneys, leading to tubular dysfunction and ultimately kidney failure.
Bone Lesions: It interferes with calcium metabolism, resulting in osteomalacia and osteoporosis.
Respiratory Issues: Chronic inhalation can cause emphysema and lung cancer.
Cardiovascular Problems: Cadmium exposure has been linked to hypertension and cardiovascular diseases.
Carcinogenicity: The International Agency for Research on Cancer (IARC) classifies cadmium as a human carcinogen.

How is Cadmium Toxicity Diagnosed?

Diagnosis of cadmium toxicity often involves a combination of clinical evaluation and laboratory tests. Blood and urine tests can measure cadmium levels, while imaging studies and biopsies may help assess organ damage. A detailed exposure history is also crucial for accurate diagnosis.

What Are the Treatment Options?

Treatment for cadmium toxicity primarily focuses on removing the source of exposure and providing supportive care. In cases of acute poisoning, chelation therapy may be used to bind and remove cadmium from the body. Chronic cases require management of symptoms and complications, such as renal support for kidney damage and medications to strengthen bones.

How Can Cadmium Exposure Be Prevented?

Preventing cadmium exposure involves multiple strategies, including:
Regulatory Measures: Governments can enforce regulations to limit cadmium emissions and contamination in food and water.
Workplace Safety: Industries should implement safety protocols to reduce occupational exposure, including the use of protective equipment and proper ventilation.
Public Awareness: Educating the public about the sources and risks of cadmium can help reduce exposure, especially among smokers and individuals in high-risk occupations.
Dietary Choices: Selecting foods with lower cadmium levels and ensuring a balanced diet can mitigate the risks associated with ingestion.



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