Selectivity Of P38 Inhibitors - Toxicology

Relevant Publications

Design, synthesis, and molecular docking of novel miscellaneous chalcones as p38α mitogen-activated protein kinase inhibitors.

Issue Release: 2024

Empagliflozin demonstrates cytotoxicity and synergy with tamoxifen in ER-positive breast cancer cells: anti-proliferative and anti-survival effects.

Issue Release: 2024

Synthesis and biological evaluation of -phenyl phenylhydroxamic acids containing phenothiazine with improved selectivity for class IIa histone deacetylases.

Issue Release: 2024

Discovery of 3-(2-aminobenzo[d]thiazol-5-yl) benzamide derivatives as potent anticancer agents via ROR1 inhibition.

Issue Release: 2024

Novel guanidine derivatives targeting leukemia as selective Src/Abl dual inhibitors: Design, synthesis and anti-proliferative activity.

Issue Release: 2024

MAPK-negative feedback regulation confers dependence to JAK2 signaling.

Issue Release: 2023

A patent review of MAPK inhibitors (2018 - present).

Issue Release: 2023

Function and inhibition of P38 MAP kinase signaling: Targeting multiple inflammation diseases.

Issue Release: 2023

Emerging delivery approaches for targeted pulmonary fibrosis treatment.

Issue Release: 2023

Multimodal regulation of the osteoclastogenesis process by secreted group IIA phospholipase A.

Issue Release: 2022

Targeting cap-dependent translation to inhibit Chikungunya virus replication: selectivity of p38 MAPK inhibitors to virus-infected cells due to autophagy-mediated down regulation of phospho-ERK.

Issue Release: 2021

Development of a Selective Dual Discoidin Domain Receptor (DDR)/p38 Kinase Chemical Probe.

Issue Release: 2021

Bee venom inhibits the proliferation and migration of cervical-cancer cells in an HPV E6/E7-dependent manner.

Issue Release: 2020

Structure-guided optimization of a novel class of ASK1 inhibitors with increased sp character and an exquisite selectivity profile.

Issue Release: 2020

Selective targeting of the αC and DFG-out pocket in p38 MAPK.

Issue Release: 2020

Current Insights of Inhibitors of p38 Mitogen-Activated Protein Kinase in Inflammation.

Issue Release: 2020

Discovery of a 2-pyridinyl urea-containing compound YD57 as a potent inhibitor of apoptosis signal-regulating kinase 1 (ASK1).

Issue Release: 2020

An Angle on MK2 Inhibition-Optimization and Evaluation of Prevention of Activation Inhibitors.

Issue Release: 2019

Effects of VCP979 Novel p38 Mitogen Activated Protein Kinase Inhibitor on Progression of Pancreatic Cancer in Mouse Model with Diabetic Conditions.

Issue Release: 2019

Synthesis and Biological Evaluation of 3-Arylindazoles as Selective MEK4 Inhibitors.

Issue Release: 2019

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