Advances in Poison Control and Toxicology: Key Findings and Trends

It can be seen that the area of poison control and toxicology has seen tremendous progress in the recent past due to improvements in display, collection of data, and awareness of toxic agents. The developments in the topic have not only upgraded our contribution and treatment of poisonings but also obstructed preventative measures required to reduce risks as well. In this article, the author describes the recent studies and developments in poison control and toxicology concerning their research roadmap that will influence the evolution of poison control in the future.

Advances in Machine Learning and Poison Control

The application of machine learning in poison control has brought drastic changes in the field, mainly in the detection and handling of cases involving poisoning. Researchers working in the latest years have concentrated on the case of data poisoning attacks in terms of the machine learning system vulnerability at which certain data can interfere with the learning process. An outstanding piece of work expanded poisoning attacks to multiclass problems and put forth a new algorithm that utilizes back-gradient optimization. This makes the attack considerably easier and is effective across a wide range of learning algorithms, as well as deep learning structures that have been used in such applications as spam filtering, malware detection, and digit recognition, among others.

Facial biometric systems are another technique used in PS to which machine learning has also been applied; however, this field has also been criticized for various weaknesses. Cutting-edge studies have presented how adversarial attacks can be performed by toggling the physical appearance by making changes to the exterior appearance, such as glasses and more. This is an appropriate reminder as to why secure approaches should be implemented when applying machine learning, for instance, in surveillance and security.

Deep learning, especially through the employment of deep residual networks, is notable for progressive developments in image recognition tasks that are useful in toxicology research. These networks, which are deeper than the conventional models, are easier to settle and provide more accurate results. It has implications for the enhancement of the diagnosis and classification of extensive multiplex toxicological results for better therapeutic plans.

Yearwise Publication Trend on toxicology

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Poison Data Systems and Surveillance

The AAPCC NPDS has been very helpful in offering near-real-time surveillance information on poison exposures and other related events. The annual report of 2018 revealed that though global total encounters were slightly lower, serious outcomes were higher, proving the fact that the encounter trend has changed and is now mainly oriented towards serious cases. The findings thus emphasize the relevance of poison centers and their involvement in the prevention and management of toxication.

Humidifier Disinfectant and Lung Injury

Another PM event that caused a major concern in Korea was the cases of humidifier disinfectant (HD)-related lung injuries. Some brands of disinfectants and chemicals, especially PHMG-P, were found to be linked to increased rates of lung injuries. This has seen society shift focus and put more effort into ensuring that such disasters are prevented through the improvement of regulations or public awareness.

European Legislation on Chemicals

New modifications that were introduced by the European Union concerning chemicals, such as the CLP and the REACH regulations, have affected poison control centers in the recent past. These regulations simplify the procedures of categorizing, labeling, and packaging substances to avoid any differences in safety among the member countries. In other words, for poison centers, the new legislation provides for better notification of data and a better understanding of the regulation of hazardous substances.

Selenium Toxicity from Dietary Supplements

One well-documented incident of acute selenium poisoning in the USA targeted unregulated supplements as a major threat. A case of poisoning was realized after an outbreak resulting from a poisonous substance called selenium in a supplement, which was found to contain the substance 200 times the labeled quantity. This experience also brought into the limelight the major issue of quality control for the production of dietary supplements to avoid cases of toxic substances in the products.

Flu Season and Newborn Baby Toxicology

There have also been studies on the connection between viral infections and late-onset diseases that are neonatal and caused by GBS. Journals proved the studies with proof that viral infections cause or worsen GBS infections in neonates, which have complications including meningitis and septicemia. It is important to get insight into these interactions to design efficient means of prevention as well as interventions in neonatal health.

Recent Publications on toxicology

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Industrial Suburbanization and Environmental Health

The literature review on historical changes in industrial suburbanization in North America explains how the industrial setting has affected urban health. Decentralization of industry as a process is relatively misunderstood as a ‘new thing,’ but in fact, it has a history that brings far-reaching consequences concerning exposure to the products of such industries and their effects on the environment. This is why further research and regulation to tackle the effects of these ventures on the health of people is required.

Conclusion

New findings in the area of poison control and toxicology play an important role in improving the safety of the population. With the charging of machine learning algorithms for poisoning detection and corresponding reactions to such phenomena up to the regulating measures standing for chemical safety, the field is actively developing to tackle the new challenges. Further studies, better monitoring, and effective laws are the factors that can help reduce the risks and prevent adverse effects from all those hazardous substances.

[keywords_start]Poison control, Toxicology, Machine learning, Data poisoning, Facial recognition, Deep learning, Poison data systems, Humidifier disinfectant, Lung injury, European legislation, Selenium toxicity, Group B Streptococcus, Industrial suburbanization
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References

  1. Muñoz-González, L., Biggio, B., Demontis, A., Paudice, A., Wongrassamee, V., Lupu, E.C. and Roli, F., 2017, November. Towards poisoning of deep learning algorithms with back-gradient optimization. In Proceedings of the 10th ACM workshop on artificial intelligence and security (pp. 27-38).
  2. Sharif, M., Bhagavatula, S., Bauer, L. and Reiter, M.K., 2016, October. Accessorize to a crime: Real and stealthy attacks on state-of-the-art face recognition. In Proceedings of the 2016 acm sigsac conference on computer and communications security (pp. 1528-1540).
  3. He, K., Zhang, X., Ren, S. and Sun, J., 2016. Deep residual learning for image recognition. In Proceedings of the IEEE conference on computer vision and pattern recognition (pp. 770-778).
  4. Szegedy, C., Vanhoucke, V., Ioffe, S., Shlens, J. and Wojna, Z., 2016. Rethinking the inception architecture for computer vision. In Proceedings of the IEEE conference on computer vision and pattern recognition (pp. 2818-2826).
  5. Gummin, D.D., Mowry, J.B., Spyker, D.A., Brooks, D.E., Beuhler, M.C., Rivers, L.J., Hashem, H.A. and Ryan, M.L., 2019. 2018 Annual report of the American Association of Poison control centers’ National Poison Data System (NPDS): 36th annual report. Clinical toxicology57(12), pp.1220-1413.
  6. Ryu SH, Park DU, Lee E, Park S, Lee SY, Jung S, Hong SB, Park J, Hong SJ. Humidifier disinfectant and use characteristics associated with lung injury in Korea. Indoor Air. 2019 Sep;29(5):735-747. doi: 10.1111/ina.12585. Epub 2019 Jul 31. PMID: 31278778.
  7. Park D. Major concerns regarding lung injury and related health conditions caused by the use of humidifier disinfectant. Environ Health Toxicol. 2016 Jul 16;31:e2016014. doi: 10.5620/eht.e2016014. PMID: 27431912; PMCID: PMC4977693.

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