Richard A. Manderville - Toxicology

Author Information

Richard A. Manderville is a prominent researcher based in the Department of Chemistry & Toxicology at the University of Guelph, located in Guelph, Ontario, Canada. His work is primarily focused on the intersection of chemistry and toxicology, where he contributes significantly to the understanding of molecular interactions and biosensing technologies. His expertise is reflected in his extensive research on DNA interactions and fluorescence-based detection methods.

Research Contributions

Richard A. Manderville has made substantial contributions to the field of chemistry and toxicology through his research on nucleobase surrogates, biosensing applications, and G-quadruplex structures. His studies often explore the design and application of fluorescent probes for detecting various biomolecular interactions, particularly focusing on turn-on fluorescence mechanisms and their potential applications in biosensing. His recent work includes the development of innovative probes for detecting protein interactions and environmental toxins like ochratoxin A.

Aliases

Throughout his academic and research career, Richard A. Manderville has been cited under several variations of his name, including R A Manderville, Richard A Manderville, Richard Manderville, and Richard A. Manderville. These aliases represent his consistent contributions across various publications and collaborations.

Publication and Citation Metrics

Total Citation Count	4544
h-index	34
Total Number of Papers	145

Publications:

Screening Internal Donor-Acceptor Biaryl Nucleobase Surrogates for Turn-On Fluorescence Affords an Aniline-Carboxythiophene Probe for Protein Detection by G-Quadruplex DNA.

DOI: 10.1021/acs.bioconjchem.1c00270

Year: 2021

Visible Fluorescent Light-up Probe for DNA Three-Way Junctions Provides Host–Guest Biosensing Applications

DOI: 10.1021/acsabm.1c00431

Year: 2021

On-Strand Knoevenagel Insertion of a Hemicyanine Molecular Rotor Loop Residue for Turn-On Fluorescence Detection of Pb-Induced G-Quadruplex Rigidity.

DOI: 10.1021/acs.bioconjchem.1c00386

Year: 2021

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DOI: 10.2174/157340721709211125160627

Year: 2021

Temperature Sensing of Thiolate Addition by Phenolate Merocyanine Dyes: Importance of the Quinone Methide Resonance Structure.

DOI: 10.1021/acs.joc.0c02428

Year: 2020

Intrinsic 'Turn-On' Aptasensor Detection of Ochratoxin A Using Energy Transfer Fluorescence.

DOI: 10.1021/acs.jafc.9b07391

Year: 2020

Ratiometric fluorescent sensing of the parallel G-quadruplex produced by PS2.M: implications for K+ detection.

DOI: 10.1039/c9an02122a

Year: 2020

Lighting Up the Thrombin-Binding Aptamer G-Quadruplex with an Internal Cyanine-Indole-Quinolinium Nucleobase Surrogate. Direct Fluorescent Intensity Readout for Thrombin Binding without Topology Switching.

DOI: 10.1021/acs.bioconjchem.0c00530

Year: 2020

Ligand-Induced G-Quadruplex Polymorphism: A DNA Nanodevice for Label-Free Aptasensor Platforms.

DOI: 10.1021/jacs.9b06533

Year: 2019

Structure of an Unusual Tetracyclic Deoxyguanosine Adduct: Implications for Frameshift Mutagenicity by Ortho‒Cyano Nitroanilines.

DOI: 10.1021/acs.chemrestox.9b00411

Year: 2019

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