Yu‐mei Tan - Toxicology

Author Information

Yuhan Tan is a distinguished researcher affiliated with the U.S. Environmental Protection Agency, Office of Pesticide Programs, Health Effects Division. Based in Research Triangle Park, NC, Dr. Tan has made significant contributions to the field of toxicology, emphasizing physiologically based pharmacokinetic (PBPK) modeling and its applications in chemical risk assessment. Dr. Tan's work is pivotal in advancing our understanding of toxicokinetic processes and their implications for regulatory assessments.

Research Contributions

Dr. Yuhan Tan has authored numerous influential papers that focus on various aspects of toxicology and computational modeling. Key areas of research include PBPK modeling, toxicokinetic processes, cumulative risk assessment, and the integration of human exposure information in animal studies. Dr. Tan's research has provided valuable insights into the nonlinear relationships between external and internal concentrations, the saturation of toxicokinetic processes, and the systematic review of published PBK models. These contributions are crucial for developing more accurate and reliable risk assessment methodologies.

Aliases

Y M Tan, Yuhan Tan, Yu-mei Tan, Yu-mei Tan

Publication and Citation Metrics

Metric	Value
Total Papers	76
Total Citations	2598
h-index	28

Publications:

Predicting nonlinear relationships between external and internal concentrations with physiologically based pharmacokinetic modeling.

DOI: 10.1016/j.taap.2022.115922

Year: 2022

Opportunities and challenges related to saturation of toxicokinetic processes: Implications for risk assessment.

DOI: 10.1016/j.yrtph.2021.105070

Year: 2021

Gaining acceptance in next generation PBK modelling approaches for regulatory assessments – An OECD international effort

DOI: 10.1016/J.COMTOX.2021.100163

Year: 2021

Incorporating human exposure information in a weight of evidence approach to inform design of repeated dose animal studies.

DOI: 10.1016/j.yrtph.2021.105073

Year: 2021

A Systematic Review of Published Physiologically-based Kinetic Models and an Assessment of their Chemical Space Coverage

DOI: 10.1177/02611929211060264

Year: 2021

PBPK model reporting template for chemical risk assessment applications

DOI: 10.1016/j.yrtph.2020.104691

Year: 2020

Development and application of physiologically-based kinetic (PBK) models

DOI: 10.1016/j.comtox.2019.100116

Year: 2020

Application of a combined aggregate exposure pathway and adverse outcome pathway (AEP-AOP) approach to inform a cumulative risk assessment: A case study with phthalates.

DOI: 10.1016/j.tiv.2020.104855

Year: 2020

A weight of evidence approach to investigate potential common mechanisms in pesticide groups to support cumulative risk assessment: A case study with dinitroaniline pesticides.

DOI: 10.1016/j.yrtph.2019.104419

Year: 2019

Chapter 2 Computational Toxicology : Application in Environmental Chemicals

DOI:

Year: 2019