yoshiaki ito - Toxicology

Author Information

Yoshiaki Ito is affiliated with the Cancer Science Institute of Singapore, National University of Singapore, Singapore 117599. His research focuses primarily on cancer biology, with a particular emphasis on molecular mechanisms and genetic factors influencing cancer progression and treatment.

Research Contributions

Yoshiaki Ito has made significant contributions to the understanding of cancer biology through his extensive research on various molecular pathways and genetic markers. His recent work includes investigations into mutations in RUNX3 affecting stem cell behavior in the stomach, the role of Helicobacter pylori CagA oncoprotein in DNA damage, and the impact of microRNAs on cartilage homeostasis. He has also explored immune evasion mechanisms in gastric cancer and the genetic engineering of hematopoietic stem cells. His research is critical in advancing the knowledge of cancer mechanisms and potential therapeutic strategies.

Aliases

Yoshiaki Ito is also known by the alias Yoshiaki Ito.

Publication and Citation Metrics

Citation Count	22,866
h-index	81
Paper Count	331

Publications:

A Point Mutation R122C in RUNX3 Promotes the Expansion of Isthmus Stem Cells and Inhibits Their Differentiation in the Stomach

DOI: 10.1016/j.jcmgh.2022.01.010

Year: 2022

The H. pylori CagA Oncoprotein Induces DNA Double Strand Breaks through Fanconi Anemia Pathway Downregulation and Replication Fork Collapse

DOI: 10.3390/ijms23031661

Year: 2022

Both microRNA-455-5p and -3p repress hypoxia-inducible factor-2α expression and coordinately regulate cartilage homeostasis

DOI: 10.1038/s41467-021-24460-7

Year: 2021

Disruption of Her2-Induced PD-L1 Inhibits Tumor Cell Immune Evasion in Patient-Derived Gastric Cancer Organoids

DOI: 10.3390/cancers13246158

Year: 2021

Highly efficient Runx1 enhancer eR1-mediated genetic engineering for fetal, child and adult hematopoietic stem cells

DOI: 10.1101/2021.11.24.469958

Year: 2021

Super-enhancers for RUNX3 are required for cell proliferation in EBV-infected B cell lines.

DOI: 10.1016/j.gene.2021.145421

Year: 2021

The Multiple Interactions of RUNX with the Hippo–YAP Pathway

DOI: 10.3390/cells10112925

Year: 2021

MicroRNA Expression Profiling, Target Identification, and Validation in Chondrocytes.

DOI: 10.1007/978-1-0716-1119-7_11

Year: 2021

Induction of gastric cancer by successive oncogenic activation in the corpus.

DOI: 10.1053/j.gastro.2021.08.013

Year: 2021

Hedgehog transcriptional effector GLI mediates mTOR-Induced PD-L1 expression in gastric cancer organoids.

DOI: 10.1016/j.canlet.2021.06.007

Year: 2021