How Does Gilbert's Syndrome Affect Drug Metabolism?
The reduced activity of the UDP-glucuronosyltransferase enzyme in Gilbert's syndrome can impact the metabolism of various drugs. This enzyme plays a significant role in the phase II detoxification process, where it aids in the glucuronidation of drugs, a process that makes them more water-soluble and easier to excrete. As a result, individuals with Gilbert's syndrome may experience altered drug metabolism, potentially leading to increased drug levels and heightened risk of adverse effects for certain medications.
