What are the Challenges of Silencing in Toxicology?
Despite its potential, gene silencing in toxicology faces several challenges. One major issue is the delivery of silencing agents to specific tissues or cells, which can limit the effectiveness of the approach. Off-target effects, where non-target genes are unintentionally silenced, also pose a significant problem. Additionally, the variability in response among different organisms or even individual cells can complicate the interpretation of results.
