Gilbert's syndrome is a hereditary disorder caused by a mutation in the UGT1A1 gene. This mutation leads to reduced activity of the enzyme UDP-glucuronosyltransferase, which is responsible for converting unconjugated bilirubin into a form that can be excreted from the body. As a result, individuals with Gilbert's syndrome often have elevated levels of unconjugated bilirubin in their blood, leading to mild jaundice. It is estimated that up to 10% of the population may have this condition, although many remain asymptomatic.
