Pharmacodynamic (pd) - Toxicology

Relevant Publications

Single molecule array measures of LRRK2 kinase activity in serum link Parkinson\'s disease severity to peripheral inflammation.

Issue Release: 2024

Comparative pharmacodynamics and dose optimization of liposomal amphotericin B against species in an pharmacokinetic/pharmacodynamic model.

Issue Release: 2024

Phase I studies of davoceticept (ALPN-202), a PD-L1-dependent CD28 co-stimulator and dual PD-L1/CTLA-4 inhibitor, as monotherapy and in combination with pembrolizumab in advanced solid tumors (NEON-1 and NEON-2).

Issue Release: 2024

Pharmacokinetic/Pharmacodynamic modelling of Saxagliptin and its active metabolite, 5-hydroxy Saxagliptin in rats with Type 2 Diabetes Mellitus.

Issue Release: 2024

Translational PK/PD and the first-in-human dose selection of a PD1/IL15: an engineered recombinant targeted cytokine for cancer immunotherapy.

Issue Release: 2024

Use of population pharmacokinetic-pharmacodynamic modelling to inform antimalarial dose optimization in infants.

Issue Release: 2024

Pharmacokinetic-Pharmacodynamic (PK-PD) Analysis of Second-Line Anti-Tubercular Drugs in Indian Children with Multi-Drug Resistance.

Issue Release: 2024

Pharmacokinetic enhancement of oncolytic virus M1 by inhibiting JAK‒STAT pathway.

Issue Release: 2024

Pharmacokinetic/pharmacodynamic relationships of enrofloxacin against Klebsiella pneumoniae in an in vivo infection model in young chicks.

Issue Release: 2024

Evaluation of omadacycline regimens for community-acquired bacterial pneumonia patients infected with by pharmacokinetic/pharmacodynamic analysis.

Issue Release: 2024

Development and Validation of a Capillary Zone Electrophoresis-Tandem Mass Spectrometry Method for Simultaneous Quantification of Eight β-Lactam Antibiotics and Two β-Lactamase Inhibitors in Plasma Samples.

Issue Release: 2024

JEWELFISH: 24-month results from an open-label study in non-treatment-naïve patients with SMA receiving treatment with risdiplam.

Issue Release: 2024

An NGS-based assay for accurate detection and quantification of immune gene expression in mouse tumor models.

Issue Release: 2024

A Minimal PBPK/PD Model with Expansion-Enhanced Target-Mediated Drug Disposition to Support a First-in-Human Clinical Study Design for a FLT3L-Fc Molecule.

Issue Release: 2024

Characterizing the mechanism of action for mRNA therapeutics for the treatment of propionic acidemia, methylmalonic acidemia, and phenylketonuria.

Issue Release: 2024

Application of machine learning techniques in population pharmacokinetics/pharmacodynamics modeling.

Issue Release: 2024

Evaluation of potential drug-drug interactions with medical cannabis.

Issue Release: 2024

Guiding Dyslipidemia Treatment: A Population Pharmacokinetic-Pharmacodynamic Framework for Obicetrapib.

Issue Release: 2024

Analysis of the pharmacokinetics and efficacy of RBD1016 - A GalNAc-siRNA targeting Hepatitis B Virus X gene using semi-mechanistic PK/PD model.

Issue Release: 2024

Effectiveness of Continuous Dopaminergic Therapies in Parkinson\'s Disease: A Review of L-DOPA Pharmacokinetics/Pharmacodynamics.

Issue Release: 2024

What are Some Strategies to Mitigate Genotoxic Stress?

How is Compliance Monitored?

How Does Selenium Bioaccumulate in Aquatic Life?

What Challenges Does Pharmacogenomics Face in Toxicology?

Can Pro Apoptotic Agents be used Therapeutically?

What is the Future of Synthetic Compounds in Toxicology?

What Are the Health Implications of Mixed Exposures?

What are the Future Directions in Bioplastic Research?

How is Sample Diversity Achieved?

Why are Simulation Tools Important in Toxicology?

Pharmacodynamic (pd) - Toxicology

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