Detoxification systems are vital for maintaining homeostasis in the face of toxic threats. The liver is a primary detoxification organ that metabolizes toxins, rendering them less harmful and facilitating their excretion. The liver's enzymatic processes, such as oxidation, reduction, and conjugation, are integral to converting lipophilic toxins into hydrophilic compounds for elimination via urine or bile. Other organs, like the kidneys and lungs, also play crucial roles in excreting toxins and maintaining homeostatic balance.