Leonardo Salmena - Toxicology

Author Information

Leonardo Salmena is affiliated with the Department of Pharmacology and Toxicology at the University of Toronto and the Princess Margaret Cancer Centre, which is part of the University Health Network in Toronto, Ontario, Canada. His work primarily focuses on the mechanisms of stem cell regulation, cancer biology, particularly acute myeloid leukemia (AML) and prostate cancer, and the role of lysosomal functions in leukemogenesis.

Research Contributions

Leonardo Salmena has made significant contributions to the understanding of hematopoietic stem cell self-renewal and leukemic processes. His research has identified key molecular pathways, such as those involving miR-130a and INPP4B, that regulate leukemic stem cell differentiation and lysosomal functions. His work also extends to investigating the origins and evolution of leukemia in Down syndrome, as well as exploring potential therapies for androgen deprivation resistance in prostate cancer. His studies have advanced our knowledge of cancer biology and opened new avenues for therapeutic interventions.

Aliases

Leonardo Salmena is also known by several other names, including L Salmena, L. Salmena, and Lenny Salmena. These aliases may appear in various publications and academic references.

Publication and Citation Metrics

Metric	Value
Citation Count	18,887
H-index	36
Paper Count	131

Publications:

Identification of the global miR-130a targetome reveals a role for TBL1XR1 in hematopoietic stem cell self-renewal and t(8;21) AML.

DOI: 10.1016/j.celrep.2022.110481

Year: 2022

INPP4B drives lysosome biogenesis to restrict leukemic stem cell differentiation and promote leukemogenesis

DOI: 10.1101/2021.03.25.437029

Year: 2022

PIKfyve inhibition reveals a novel role for Inpp4b in the regulation of PtdIns(3)P and lysosome dynamics

DOI: 10.1101/2021.12.13.472440

Year: 2021

Pseudogenes: Four Decades of Discovery.

DOI: 10.1007/978-1-0716-1503-4_1

Year: 2021

Abstract P175: Investigating inositol polyphosphate-4-phosphatase, type II (INPP4B) signaling and role in acute myeloid leukemia

DOI: 10.1158/1535-7163.targ-21-p175

Year: 2021

INPP4B promotes leukemia by restricting leukemic stem cell differentiation through regulation of lysosomal functions

DOI: 10.1101/2021.03.25.437029

Year: 2021

Identification of the Global miR-130a Targetome Reveals a Novel Role for TBL1XR1 in Hematopoietic Stem Cell Self-Renewal and t(8;21) AML

DOI: 10.1101/2021.07.30.454489

Year: 2021

Reactive oxygen species prevent lysosome coalescence during PIKfyve inhibition

DOI: 10.1371/journal.pone.0259313

Year: 2021

Mapping the cellular origin and early evolution of leukemia in Down syndrome

DOI: 10.1126/science.abf6202

Year: 2021

Author Correction: A co-clinical approach identifies mechanisms and potential therapies for androgen deprivation resistance in prostate cancer

DOI: 10.1038/s41588-020-0701-7

Year: 2020

What are Some Challenges Associated with MEMS in Toxicology?

How has Genomics Revolutionized Toxicology?

Why is Theoretical Knowledge Important?

What are the Challenges in Maintaining Study Registries?

What is Gestation?

What Challenges Exist in Developing Less Hazardous Syntheses?

Are Protists Used in Bioremediation?

What is the Role of Procaspases in Toxicology?

What Does Elevated 8-OHdG Indicate?

What Are Cellular Responses in Toxicology?

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