Are Biotransformation Enzymes Involved in Carcinogenesis?
Yes, some biotransformation enzymes are involved in the activation of procarcinogens to carcinogens. Certain Phase I enzymes can bioactivate chemicals into reactive metabolites that can bind to DNA, leading to mutations and potentially initiating the process of carcinogenesis. Conversely, Phase II enzymes generally detoxify and facilitate the excretion of these substances, highlighting their dual role in both protection and risk.
