Some crosslinking agents have been classified as potential carcinogens. For instance, formaldehyde is a well-known example that has been linked to nasal and nasopharyngeal cancers. Its mechanism of carcinogenicity involves the formation of DNA adducts, leading to mutations. The International Agency for Research on Cancer (IARC) has classified formaldehyde as a Group 1 carcinogen, indicating sufficient evidence of carcinogenicity in humans.