Are There Specific Examples Where Flexible Regions Play a Role in Toxicity?
Yes, numerous examples in toxicology highlight the role of flexible regions. For instance, the flexibility in the binding site of the Cytochrome P450 enzymes can lead to varied metabolic pathways for drugs and chemicals, influencing their toxicity. Similarly, the flexibility in the receptor-ligand interactions of the estrogen receptor allows for the binding of endocrine disruptors, which can lead to adverse reproductive effects.
