Yes, enzymes can significantly influence the toxicity of chemicals. The activity and expression levels of metabolic enzymes can vary greatly between individuals due to genetic polymorphisms, diet, age, or exposure to other chemicals. For instance, variations in CYP2D6 can lead to differences in drug metabolism, affecting both efficacy and toxicity. Enzymes can also convert procarcinogens into active carcinogens, thereby influencing susceptibility to cancer.
