Prevention of ototoxicity involves careful monitoring of drug levels, minimizing exposure duration, and using the lowest effective doses. In some cases, alternative medications with lower ototoxic potential can be used. Antioxidants and protective agents, such as N-acetylcysteine, are under investigation for their potential to mitigate ototoxic effects. Once ototoxicity occurs, management focuses on rehabilitation through hearing aids, cochlear implants, and supportive therapies.