Orlistat can interact with other medications, potentially affecting their absorption and efficacy. For example, it can reduce the absorption of fat-soluble vitamins (A, D, E, K). Therefore, patients are often advised to take a multivitamin supplement at least two hours before or after taking orlistat. It may also interfere with the absorption of certain medications like cyclosporine and levothyroxine, necessitating dose adjustments or monitoring.
