How are Antimitotic Agents Metabolized and Excreted?
The metabolism and excretion of antimitotic agents can vary significantly depending on the specific compound. Many are metabolized by the liver and excreted via the kidneys. The cytochrome P450 enzyme system often plays a crucial role in their biotransformation. Understanding these pathways is essential for predicting drug interactions and potential toxicities. For example, inhibitors or inducers of cytochrome P450 can significantly alter the pharmacokinetics of these agents, leading to increased toxicity or reduced efficacy.
