Fragrance chemicals undergo various safety assessments to evaluate their potential toxicological risks. These assessments often include in vitro testing, which uses cell cultures to study the effects of chemicals on biological systems. In addition, in vivo testing using animal models may be conducted to understand the effects of long-term exposure. Regulatory bodies such as the Environmental Protection Agency (EPA) and the European Chemicals Agency (ECHA) have developed guidelines for the safe use of fragrance chemicals. However, the complexity of fragrance formulations can make risk assessment challenging.
