Once absorbed, toxicants are distributed throughout the body via the bloodstream. The distribution largely depends on the chemical properties of the toxicant, such as its solubility, molecular size, and affinity for certain tissues. Lipid-soluble toxicants tend to accumulate in fatty tissues, while water-soluble toxicants are more likely to be found in bodily fluids. The blood-brain barrier can restrict the distribution of certain toxicants, protecting the central nervous system from harmful substances.
