- Sample Preparation: Techniques such as [solid-phase extraction]() (SPE), [protein precipitation](), and liquid-liquid extraction can help remove interfering substances. - Internal Standards: The use of stable isotope-labeled internal standards can compensate for matrix effects by normalizing the signal. - Matrix Matching: Using calibration standards prepared in a matrix similar to the sample can help account for matrix-related variations. - Dilution: Diluting the sample can reduce the concentration of interfering substances, thereby minimizing matrix effects.
