Mitigating the toxicity of alkylating agents involves several strategies:
1. Dose Adjustment: Careful titration of the dose based on the patient's condition and response can help minimize adverse effects.
2. Protective Agents: Co-administration of protective agents like mesna with cyclophosphamide can help prevent bladder toxicity.
3. Hydration and Diuresis: Ensuring adequate hydration and promoting urine flow can reduce the risk of renal toxicity, especially with agents like cisplatin.
4. Monitoring and Supportive Care: Regular monitoring of blood counts and organ function, coupled with supportive care measures like growth factor administration or antibiotic prophylaxis, can help manage side effects.
