Biological rhythms, such as the circadian rhythm, regulate various physiological functions, including detoxification processes. The liver, a primary organ for detoxification, exhibits circadian variations in enzyme activity. For instance, the expression of cytochrome P450 enzymes, crucial for metabolizing drugs and toxins, can vary throughout the day. Hence, the ability of the liver to process toxicants and drugs can change based on the time of exposure, influencing toxicity levels.
