How Do Efflux Transporters Affect Drug Resistance?
Efflux transporters are implicated in the phenomenon of drug resistance, particularly in cancer therapy. By actively pumping chemotherapy drugs out of cancer cells, transporters like P-glycoprotein reduce the intracellular concentration of these drugs, leading to decreased efficacy and treatment failure. Understanding the role of efflux transporters in drug resistance can help in developing strategies to overcome this challenge in clinical settings.
