How Do Enzyme Deficiencies Affect Drug Metabolism?
Enzyme deficiencies can lead to altered drug metabolism, which may cause adverse drug reactions or therapeutic failure. For example, a deficiency in cytochrome P450 enzymes, which are crucial for drug metabolism, can result in slower clearance of drugs from the body, leading to potential toxicity. Conversely, an increased rate of drug metabolism due to enzyme variations can result in subtherapeutic drug levels.
