How Do Feedback Loops Affect Toxicological Responses?
Feedback loops can modify the toxicokinetics and toxicodynamics of substances, influencing the absorption, distribution, metabolism, and excretion (ADME) of toxins. For example, the liver uses feedback mechanisms to regulate enzyme levels, which can enhance or reduce the metabolism of toxic substances. This regulation affects how quickly a toxin is broken down and cleared from the body, impacting overall toxicity.
