How Do Genetic Differences Influence Drug Metabolism?
Genetic variations can significantly impact drug metabolism. The human genome harbors numerous polymorphisms in genes encoding drug-metabolizing enzymes, such as the Cytochrome P450 family. These genetic variants can alter enzyme activity, resulting in either rapid or slow metabolism of drugs. For instance, individuals with certain CYP2D6 polymorphisms may metabolize drugs like codeine more efficiently, leading to increased risk of adverse effects.
