How Do Genetic Disorders Affect Toxicological Outcomes?
Genetic disorders can affect the way an individual's body processes chemicals, including metabolism, distribution, and excretion. For example, variations in genes that encode for enzymes involved in drug metabolism can lead to altered drug efficacy or increased risk of toxicity. Disorders such as Phenylketonuria (PKU) result from a mutation in the gene responsible for breaking down the amino acid phenylalanine, leading to toxic accumulation if untreated.
