How Do Genetic Variations Affect Detoxifying Enzymes?
Genetic polymorphisms can significantly impact the activity of detoxifying enzymes, leading to variations in the detoxification capacity among individuals. For example, certain polymorphisms in the CYP2D6 enzyme can result in poor, intermediate, extensive, or ultra-rapid metabolism of substrates. These differences can influence an individual's susceptibility to adverse drug reactions or toxin exposure.
