Isoenzymes can significantly alter the pharmacokinetics of drugs. Different isoenzymes can metabolize the same drug at different rates, affecting its concentration in the bloodstream and tissues. For instance, the isoenzymes CYP3A4 and CYP2D6 metabolize a substantial proportion of pharmaceutical drugs. Variability in these isoenzymes due to genetic polymorphisms can lead to differences in drug response and adverse effects among individuals. Understanding these differences allows for more personalized approaches to medicine, known as pharmacogenomics.
