NMDRs pose a challenge to existing regulatory frameworks, which often rely on the assumption of monotonic dose-response relationships. Regulators must consider whether current testing guidelines adequately capture potential low-dose effects of chemicals. This might require revising testing protocols, adding low-dose testing requirements, and updating risk assessment models. The presence of NMDRs necessitates a more nuanced approach to chemical safety evaluation, potentially affecting the regulation of pharmaceuticals, pesticides, industrial chemicals, and consumer products.
