How do Organophosphates Affect Acetylcholinesterase?
Organophosphates inhibit AChE by phosphorylating the serine hydroxyl group in the active site of the enzyme. This inhibition is often irreversible or slowly reversible, leading to prolonged effects. Symptoms of organophosphate poisoning include muscle twitching, respiratory distress, convulsions, and potentially death if untreated.
