The interaction between plasma proteins and toxicants is fundamental to understanding toxicokinetics, which is the study of how toxins are absorbed, distributed, metabolized, and excreted from the body. Plasma proteins, such as albumin and globulins, can bind to toxicants, affecting their bioavailability and elimination. This binding can either mitigate or exacerbate the toxic effects depending on the nature of the toxin and the protein involved.