cardiomyocyte apoptosis

How Do Toxicants Induce Cardiomyocyte Apoptosis?

Toxicants can trigger cardiomyocyte apoptosis through various pathways. Some common mechanisms include oxidative stress, mitochondrial dysfunction, and activation of apoptotic signaling pathways. For instance, heavy metals like cadmium and lead can increase oxidative stress, leading to cellular damage. Additionally, certain drugs and chemicals can interfere with mitochondrial function, causing energy depletion and triggering apoptosis.

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