Absorption: Changes in gastrointestinal function can affect the absorption rate of orally ingested toxins. Distribution: Age-related changes in body composition, such as increased fat and decreased muscle mass, can alter the distribution of lipophilic and hydrophilic substances. Metabolism: Decline in liver function with age can reduce the body's ability to metabolize toxins, leading to prolonged exposure. Excretion: Reduced kidney function in older adults can impair the excretion of toxic substances, increasing their potential toxicity.
