Enzymatic degradation typically occurs in two phases. In [Phase I](), enzymes such as cytochrome P450 introduce reactive or polar groups into toxins through oxidation, reduction, or hydrolysis. In [Phase II](), the products of Phase I reactions are conjugated with endogenous molecules like glutathione, sulfate, or glucuronic acid, making them more water-soluble. This facilitates their excretion through urine or bile.
