The hydrophilic nature of a compound significantly influences its toxicokinetics, which includes absorption, distribution, metabolism, and excretion (ADME). Hydrophilic chemicals are generally absorbed less efficiently through lipid-rich biological membranes than lipophilic substances. However, once in the bloodstream, they are easily transported, as blood is primarily water. Metabolism often increases hydrophilicity, aiding in the excretion of toxicants via urine.
