Once ingested, MSG is metabolized similarly to naturally occurring glutamate found in foods. In the human body, glutamate functions as a neurotransmitter, playing a crucial role in brain function. However, the glutamate from dietary sources, including MSG, does not cross the blood-brain barrier in significant amounts, mitigating concerns about neurological effects. Most of the glutamate from dietary sources is used as an energy source or in the synthesis of proteins and other biomolecules.