The route of exposure significantly affects the absorption, distribution, metabolism, and excretion (ADME) of substances, influencing their toxicity. For instance:
Inhalation: Substances absorbed through the lungs can rapidly enter the bloodstream, leading to systemic effects. Ingestion: Chemicals entering through the digestive tract may be metabolized by the liver, which can modify their toxic potential. Dermal contact: The skin acts as a barrier, but certain chemicals can penetrate and cause local or systemic effects.
