How Does Synergism Differ from Other Interactions?
In toxicology, interactions between chemicals can be classified into several types: additive, antagonistic, and synergistic. An additive effect occurs when the combined effect of substances is equal to the sum of their individual effects. In contrast, an antagonistic effect happens when the combined effect is less than expected. Synergism, however, results in an effect greater than the sum, posing unique challenges in risk assessment and regulatory frameworks.
