How Does the Concept of Bioavailability Affect Dose Assessment?
Bioavailability refers to the proportion of a substance that enters the circulation when introduced into the body and is thus able to have an active effect. It affects dose assessment as it determines the actual dose that reaches the target organs or tissues. Factors like absorption rate, distribution, metabolism, and excretion influence bioavailability and, consequently, the potential toxicity of a substance.
