How does the inhibition of UGTs affect drug interactions?
UGT inhibition can lead to significant drug interactions, affecting the pharmacokinetics and toxicity of co-administered drugs. Certain drugs and natural products, such as grapefruit juice, can inhibit UGT activity, leading to increased levels of drugs that are UGT substrates. This can enhance drug toxicity or lead to unexpected side effects, underscoring the importance of considering UGT interactions in drug therapy.