The liver is the primary organ for detoxification. It performs this function through biotransformation, which occurs in two phases. In Phase I, the liver uses enzymes such as cytochrome P450 to convert toxins into more water-soluble intermediates. In Phase II, these intermediates undergo conjugation, where they are bound to substances like glucuronic acid, sulfate, or glutathione, making them easier to excrete. These two phases help transform fat-soluble toxins into water-soluble substances that can be eliminated via urine or bile.
