Toxicologists are particularly interested in GVHD because the condition can alter the pharmacokinetics and pharmacodynamics of drugs. For example, the liver and gastrointestinal tract are common targets of GVHD, affecting drug metabolism and absorption. This necessitates careful monitoring and adjustment of drug dosages to prevent toxicity. Additionally, toxicologists study how drugs used to treat GVHD, like methotrexate and cyclosporine, can lead to toxicities, including hepatotoxicity and nephrotoxicity.
