Lipogenesis is tightly regulated by hormonal and nutritional factors. Insulin, a hormone released by the pancreas, is a potent stimulator of lipogenesis, promoting the uptake of glucose and its conversion into fatty acids. Conversely, glucagon and adrenaline inhibit lipogenesis. Nutritional factors such as a high-carbohydrate diet can also enhance lipogenic activity. In toxicological studies, disruptions in these regulatory mechanisms can lead to altered lipid metabolism, affecting how the body handles chemical exposure.
