Interferon Gamma Release Assays (IGRAs) are diagnostic tests used primarily to detect immune responses to Mycobacterium tuberculosis, the bacterium that causes tuberculosis (TB). These assays measure the release of interferon-gamma (IFN-γ) from T-cells in blood samples when exposed to specific antigens. While their primary application is in TB diagnostics, the principles of IGRAs have potential applications in toxicology.