What Are the Applications of Sequencing in Toxicogenomics?
Toxicogenomics combines toxicology with genomics to study the effects of chemicals on genes and their functions. Sequencing technologies facilitate toxicogenomics by:
Identifying Toxigenic Variants: Sequencing can detect genetic variations that may influence an organism's response to toxicants. Gene Expression Profiling: RNA sequencing (RNA-seq) is used to assess changes in gene expression patterns upon exposure to toxic substances. Pathway Analysis: Sequencing helps in identifying biological pathways affected by toxic exposure, providing insights into the mechanisms of toxicity.
