What are the Challenges in Dermal Toxicity Testing?
Several challenges are associated with dermal toxicity testing:
Variability in Human Skin: Human skin varies significantly in terms of thickness, permeability, and sensitivity, complicating the extrapolation of data from animal models or in vitro systems to humans. Complex Chemical Interactions: Some substances may interact with each other or with skin components, leading to unpredictable toxic effects. Ethical and Practical Constraints: The push for reducing animal testing and the need for rapid testing methods pose challenges in developing reliable and comprehensive testing protocols.
