What are the Challenges in Developing Chemotherapy Prodrugs?
Despite their potential benefits, the development of chemotherapy prodrugs is not without challenges. Identifying the right conversion mechanism and ensuring selective activation within tumor cells can be complex. Additionally, interpatient variability in enzyme expression and activity may lead to differences in drug efficacy and toxicity. Regulatory hurdles and the need for extensive clinical testing to demonstrate both safety and efficacy further complicate the development process.
